The singles competition of the 2001 Open SEAT Godó tennis tournament was held in April 2001. Marat Safin was the defending champion but did not compete that year.
Juan Carlos Ferrero won in the final 4–6, 7–5, 6–3, 3–6, 7–5 against Carlos Moyá.[1]
A champion seed is indicated in bold text and the round in which that seed was eliminated is indicated in italic text. The top eight seeds received a bye to the second round.