See main article: 2001 Swisscom Challenge.
Lindsay Davenport defeated Jelena Dokic in the final, 6–3, 6–1 to win the singles tennis title at the 2001 Swisscom Challenge.
Martina Hingis was the reigning champion, but withdrew due to an ankle injury.
The top four seeds received a bye into the second round. Martina Hingis, the first seed, dropped out of the tournament. Her bye was given to number nine seed Sandrine Testud.