| Election Name: | 2001 St. Louis mayoral election |
| Flag Image: | Flag of St. Louis, Missouri.svg |
| Previous Election: | 1997 St. Louis mayoral election |
| Previous Year: | 1997 |
| Election Date: | April 3, 2001 |
| Next Election: | 2005 St. Louis mayoral election |
| Next Year: | 2005 |
| Turnout: | 13.61% |
| Candidate1: | Francis Slay |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 41,472 |
| Percentage1: | 87.51% |
| Candidate2: | Mike Chance |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 5,917 |
| Percentage2: | 12.49% |
| Type: | Mayor |
| Ongoing: | No |
| Map Size: | 200px |
| Mayor | |
| Before Election: | Clarence Harmon |
| Before Party: | Democratic Party (United States) |
| After Election: | Francis Slay |
| After Party: | Democratic Party (United States) |
The 2001 St. Louis mayoral election was held on April 3, 2001[1] to elect the mayor of St. Louis, Missouri. It saw the election of Francis Slay and the defeat of incumbent mayor Clarence Harmon in the Democratic primary.
The election was preceded by party primaries on March 6.