| Competition: | S. League |
| Season: | 2001 |
| Winners: | Geylang United 2nd S.League title |
| Continentalcup1: | AFC Champions League |
| Continentalcup1 Qualifiers: | Geylang United (S.League winners) Home United (Singapore Cup winners) |
| Matches: | 198 |
| Total Goals: | 689 |
| League Topscorer: | Mirko Grabovac (42) |
| Biggest Home Win: | Singapore Armed Forces 8-2 Tampines Rovers (18 August 2001) |
| Biggest Away Win: | Sembawang Rangers 0-6 Singapore Armed Forces (30 March 2001) |
| Highest Scoring: | Singapore Armed Forces 8-2 Tampines Rovers (18 August 2001) |
| Prevseason: | 2000 |
| Nextseason: | 2002 |
2001 S.League was the sixth season of Singapore's professional football league. It was won by Geylang United, which was their second league title.
Each club is allowed to have up to a maximum of 4 foreign players.
| Club | Player 1 | Player 2 | Player 3 | Player 4 | Player 5 (Prime League) | Former Player | |
|---|---|---|---|---|---|---|---|
| None | |||||||
| None | |||||||
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| Rank | width='150' | Name! | width='140' | Club! | Goals |
|---|---|---|---|---|---|
| 1 |  Mirko Grabovac | Singapore Armed Forces | 42 | ||
| 2 |  Aleksandar Đurić | Geylang United | 34 | ||
| 3 |  Egmar Goncalves | Home United | 28 | ||
| 4 | Brian Bothwell | Geylang United | 23 | ||
| 5 | Indra Sahdan Daud | Home United | 22 | ||
| 6 | Peres de Oliveira | Home United | 21 | ||
| 7 | Park Tae-Won | Jurong | 18 | ||
| 8 | Tom English | Marine Castle United | 15 | ||
| 9 |  Michiaki Kakimoto | Clementi Khalsa | 14 | ||
| 9 | Toh Choon Ming | Jurong | 14 | ||
| 9 |  Kiatisuk Senamuang | Singapore Armed Forces | 14 | ||
Source:[1]