| Competition: | Campeonato Nacional Copa Banco del Estado |
| Dates: | 3 March – 9 December 2001 |
| Winners: | Santiago Wanderers (3rd title) |
| Relegated: | O'Higgins Deportes Puerto Montt |
| Matches: | 240 |
| Total Goals: | 719 |
| Continentalcup1: | 2002 Copa Libertadores |
| Continentalcup1 Qualifiers: | Santiago Wanderers Universidad Católica (2nd place) Cobreloa (Liguilla winners) |
| League Topscorer: | Héctor Tapia (24) |
| Attendance: | 1,449,298 |
| Average Attendance: | 6,038 |
| Prevseason: | 2000 |
| Nextseason: | 2002-A |
The 2001 Campeonato Nacional was Chilean first tier's 70th season which Santiago Wanderers reached its third professional title after 33 years.[1]
Cobreloa qualified for the 2001 Copa Libertadores