The 2001 Marshall Thundering Herd football team represented Marshall University in the 2001 NCAA Division I-A football season. The Thundering Herd played their home games at Marshall University Stadium in Huntington, West Virginia, and competed in the East Division of the Mid-American Conference (MAC). The team was coached by sixth-year head coach Bob Pruett. Marshall finished the season with a 64–61 win over East Carolina in the GMAC Bowl. It was the highest scoring bowl game in college football history.
The game between Marshall and TCU was canceled due to the September 11 attacks.
The following players were selected in the 2002 NFL draft.
| Player | Position | Round | Pick | Franchise |
| Chris Massey | Fullback | 7 | 243 | St. Louis Rams |