| Year: | 2001 |
| Team: | Louisville Cardinals |
| Conference: | Conference USA |
| Short Conf: | C-USA |
| Coachrank: | 16 |
| Aprank: | 17 |
| Record: | 11–2 |
| Conf Record: | 6–1 |
| Hc Year: | 4th |
| Oc Year: | 3rd |
| Def Coach: | Chris Smeland |
| Dc Year: | 4th |
| Champion: | C-USA champion Liberty Bowl champion |
| Bowl Result: | W 28–10 vs. BYU |
The 2001 Louisville Cardinals football team represented the University of Louisville in the 2001 NCAA Division I-A football season. The team, led by John L. Smith, played their home games in Papa John's Cardinal Stadium. They ended the season with an 11–2 record.