Jennifer Capriati defeated Martina Hingis in the final, 6–0, 4–6, 6–4 to win the singles tennis title at the 2001 Family Circle Cup.
Mary Pierce was the defending champion, but lost in the third round to Amy Frazier.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top eight seeds received a bye to the second round.