The 2001 Esiliiga is the 11th season of the Esiliiga, second-highest Estonian league for association football clubs, since its establishment in 1992.
FC Lootus Kohtla-Järve beat FC Valga 2–2 on away goals rule. Lootus remained in Meistriliiga, Valga in Esiliiga.
TJK-83 Tallinn beat Hiiumaa ÜJK Emmaste 7–0 on aggregate. TJK-83 promoted to Esiliiga, Emmaste relegated to Second Division.