| Tourney Name: | Commonwealth of Independent States Cup |
| Year: | 2001 |
| Other Titles: | CIS Cup, Кубок Содружества 2001 |
| Country: | Russia |
| Dates: | 20–28 January 2001 |
| Num Teams: | 16 |
| Venues: | 2 |
| Cities: | 1 |
| Champion Other: |  Spartak Moscow |
| Count: | 6 |
| Matches: | 29 |
| Goals: | 99 |
| Top Scorer: |  Marcão Jafar Irismetov Valery Strypeykis Raman Vasilyuk Mikheil Ashvetia(4 goals) |
| Prevseason: | 2000 |
| Nextseason: | 2002 |
The 2001 Commonwealth of Independent States Cup was the ninth edition of the competition between the champions of former republics of Soviet Union. It was won by Spartak Moscow for the sixth time overall and third in a row. For the third and final time the competition was played in a two-division format (first introduced in 1999). The next year the format was changed, mostly due to relegation of Ukraine from the top division.
| Team | Qualification | Participation | |
|---|---|---|---|
| Top Division | |||
| Spartak Moscow | 2000 Russian Top Division champions | 8th | |
 Dynamo Kyiv | 1999–2000 Vyshcha Liha champions | 6th | |
| Slavia Mozyr | 2000 Belarusian Premier League champions | 2nd | |
| FBK Kaunas | 2000 A Lyga champions | 3rd | |
 Skonto Riga | 2000 Latvian Higher League champions | 9th | |
 Zimbru Chișinău | 1999–2000 Moldovan National Division champions | 8th | |
 Varzob Dushanbe | 2000 Tajik League champions | 3rd | |
 Köpetdag Aşgabat | 2000 Ýokary Liga champions | 8th | |
| First Division | |||
 Araks Ararat | 2000 Armenian Premier League champions | 2nd | |
 Shamkir | 1999–2000 Azerbaijan Top League champions | 1st | |
 Levadia Maardu | 2000 Meistriliiga champions | 2nd | |
| Torpedo Kutaisi | 1999–2000 Umaglesi Liga champions | 1st | |
 Zhenis Astana | 2000 Kazakhstan Premier League champions | 1st | |
| Dustlik Tashkent | 2000 Uzbek League champions | 2nd | |
 Zhashtyk-Ak-Altyn Kara-Suu | 2000 Kyrgyzstan League 4th team 1 | 1st | |
| Russia U21 | Unofficial entry, not eligible for promotion | 6th | |
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| Rank | Player | Team | Goals | |
|---|---|---|---|---|
| align=center rowspan="5" | 1 | Marcão | Spartak Moscow | 4 |
| Jafar Irismetov | Spartak Moscow | 4 | ||
| Valery Strypeykis | Slavia Mozyr | 4 | ||
| Raman Vasilyuk | Slavia Mozyr | 4 | ||
| Mikheil Ashvetia | Torpedo Kutaisi | 4 | ||
| align=center rowspan="5" | 6 | Umid Isoqov | Dustlik Tashkent | 3 |
| Anvarjon Soliev | Dustlik Tashkent | 3 | ||
| Hayk Hakobyan | Araks Ararat | 3 | ||
| Vidadi Rzayev | Shamkir | 3 | ||
| Sergei Rodin | Russia U21 | 3 |