| Year: | 2001 |
| Team: | Clemson Tigers |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 7–5 |
| Conf Record: | 4–4 |
| Hc Year: | 3rd |
| Oc Year: | 1st as OC, 3rd overall |
| Dc Year: | 3rd |
| Stadium: | Memorial Stadium (c. 81,473, grass) |
| Champion: | Humanitarian Bowl champion |
| Bowl Result: | W 49–24 |
The 2001 Clemson Tigers football team represented Clemson University in NCAA Division I-A college football during the 2001 season. Clemson competed as a member of the Atlantic Coast Conference (ACC).
The team was led by head coach Tommy Bowden. Brad Scott served as the offensive coordinator, and Reggie Herring served as the defensive coordinator.
The Tigers finished the season 7–5, 4–4 in ACC play and won the Humanitarian Bowl 49–24 against Louisiana Tech.