| Team: | Buffalo Destroyers |
| Year: | 2001 |
| Record: | 6–8 |
| Division Place: | 4th |
| Coach: | Ray Bentley |
| Stadium: | HSBC Arena |
| Playoffs: | did not qualify |
| Shortnavlink: | Destroyers seasons |
The 2001 Buffalo Destroyers season was the 3rd season for the franchise and the 3rd in Buffalo, New York. They finished with a 6–8 record and failed to qualify for the playoffs.
Ray Bentley started his second season as head coach of the Destroyers.
| Week | Date | Opponent | Home/Away | Result | |
|---|---|---|---|---|---|
| 1 | March 26 | Tampa Bay Storm | Home | L 27–49[1] | |
| 2 | April 7 | Oklahoma Wranglers | Away | L 41–49[2] |
| Week | Date | Opponent | Home/Away | Result | |
|---|---|---|---|---|---|
| 1 | April 14 | Toronto Phantoms | Away | W 61–54[3] | |
| 2 | April 20 | New Jersey Gladiators | Home | W 39–28[4] | |
| 3 | April 27 | New York Dragons | Away | L 58–70[5] | |
| 4 | May 4 | Carolina Cobras | Away | L 57–59[6] | |
| 5 | May 11 | Florida Bobcats | Home | W 56–48[7] | |
| 6 | May 18 | Houston Thunderbears | Home | W 57–55[8] | |
| 7 | May 26 | Arizona Rattlers | Away | L 14–50[9] | |
| 8 | June 1 | New Jersey Gladiators | Away | W 51–31[10] | |
| 9 | June 8 | New York Dragons | Home | W 58–51[11] | |
| 10 | June 17 | Carolina Cobras | Home | L 44–53[12] | |
| 11 | June 22 | Nashville Kats | Away | L 48–87[13] | |
| 12 | Bye Week | ||||
| 13 | July 6 | Toronto Phantoms | Home | L 26–61[14] | |
| 14 | July 13 | Orlando Predators | Away | L 40–48[15] | |
| 15 | July 20 | Grand Rapids Rampage | Home | L 40–44[16] |