| Score: | 6–7(10–12), 7–6(7–5), 6–4, 6–2 |
| Draw: | 128 (16 / 8) |
| Seeds: | 16 |
| Before Name: | Wimbledon Championships – Men's singles |
| After Name: | Wimbledon Championships – Men's singles |
See main article: 2000 Wimbledon Championships.
Three-time defending champion Pete Sampras defeated Patrick Rafter in the final, 6–7(10–12), 7–6(7–5), 6–4, 6–2 to win the gentlemen's singles tennis title at the 2000 Wimbledon Championships.[1] It was his record-equalling seventh Wimbledon title (matching William Renshaw's all-time record) and record-breaking 13th major title overall (surpassing Roy Emerson's all-time record).[2]
With his first round victory against Greg Rusedski, Vince Spadea ended his 21-match losing streak, the longest such streak in the Open Era.[3]
See also: 1 and 1. 
Pete Sampras (champion)
See also: 2 and 8. Andre Agassi (semifinals)
See also: 3 and 3. 
Magnus Norman (second round)
See also: 4 and 6. 
Gustavo Kuerten (third round)
See also: 5 and 5. 
Yevgeny Kafelnikov (second round)
See also: 6 and 4. 
Cédric Pioline (second round)
See also: 7 and 2. 
Lleyton Hewitt (first round)
See also: 8 and 7. 
Tim Henman (fourth round)
See also: 9 and 2. Thomas Enqvist (fourth round)
See also: 10 and 7. Mark Philippoussis (quarterfinals)
See also: 11 and 4. Richard Krajicek (second round)
See also: 12 and 5. Patrick Rafter (final)
See also: 13 and 6. Nicolas Kiefer (first round)
See also: 14 and 3. Greg Rusedski (first round)
See also: 15 and 8. Marat Safin (second round)
See also: 16 and 1. 
Nicolás Lapentti (first round)
See main article: 2000 Wimbledon Championships – Men's singles qualifying.