| Election Name: | 2000 United States Senate election in Mississippi |
| Country: | Mississippi |
| Flag Image: | Flag of Mississippi (1996-2001).svg |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1994 United States Senate election in Mississippi |
| Previous Year: | 1994 |
| Next Election: | 2006 United States Senate election in Mississippi |
| Next Year: | 2006 |
| Election Date: | November 7, 2000 |
| Image1: | File:Trent Lott official portrait (cropped).jpg |
| Nominee1: | Trent Lott |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 654,941 |
| Percentage1: | 65.88% |
| Nominee2: | Troy D. Brown |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 314,090 |
| Percentage2: | 31.59% |
| U.S. Senator | |
| Before Election: | Trent Lott |
| Before Party: | Republican Party (United States) |
| After Election: | Trent Lott |
| After Party: | Republican Party (United States) |
The 2000 United States Senate election in Mississippi was held on November 7, 2000. Incumbent Republican U.S. Senator Trent Lott won re-election to a third term.