| Turnout: | 68.4% |
| Election Name: | 2000 United States House of Representatives election in South Dakota |
| Country: | South Dakota |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1998 United States House of Representatives election in South Dakota |
| Previous Year: | 1998 |
| Next Election: | 2002 United States House of Representatives election in South Dakota |
| Next Year: | 2002 |
| Election Date: | November 7, 2000 |
| Image1: | File:John_Thune_official_photo.jpg |
| Nominee1: | John Thune |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 231,083 |
| Percentage1: | 73.42% |
| Nominee2: | Curt Hohn |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 78,321 |
| Percentage2: | 24.88% |
| Map Size: | 260px |
| U.S. Representative | |
| Before Election: | John Thune |
| Before Party: | Republican Party (United States) |
| After Election: | John Thune |
| After Party: | Republican Party (United States) |
The 2000 United States House of Representatives election in South Dakota took place on Tuesday, November 7, 2000, with a primary election on June 6. Voters selected a representative for their single at-large district, who ran on a statewide ballot. Incumbent Republican representative John Thune won the race by a wide margin, outrunning the Republican candidate for president George W. Bush by 13 points in the state.
No Republican primary was held.
Curt Hohn won the three-way Democratic primary with 56.07% of the vote. Only 13.09% of the Democratic electorate turned out to vote in the primary.
No Libertarian primary was held.