The 2000 US Open was held between August 28 – September 10, 2000. It was the final Grand Slam event of 2000.
Both Andre Agassi and Serena Williams were unsuccessful in their title defences; Agassi being upset in the second round by Arnaud Clément and Williams losing in the quarter-finals to Lindsay Davenport. Marat Safin won his first US Open title and first of two Grand Slams, defeating Pete Sampras in the final, and Venus Williams defeated Davenport to win the women's title.
See main article: 2000 US Open – Men's singles. 
Marat Safin defeated 
Pete Sampras, 6–4, 6–3, 6–3
• It was Safin's 1st career Grand Slam singles title and his 1st and only title at the US Open. It was Safin's 4th title of the year, and his 5th overall.
See main article: 2000 US Open – Women's singles. Venus Williams defeated Lindsay Davenport, 6–4, 7–5
• It was Williams' 2nd career Grand Slam singles title and her 1st title at the US Open. It was Williams' 5th title of the year, and her 14th overall.
See main article: 2000 US Open – Men's doubles. 
Lleyton Hewitt / 
Max Mirnyi[1] defeated Ellis Ferreira / Rick Leach, 6–4, 5–7, 7–6
• It was Hewitt's 1st and only career Grand Slam doubles title.
• It was Mirnyi's 1st career Grand Slam doubles title.
See main article: 2000 US Open – Women's doubles. 
Julie Halard-Decugis / 
Ai Sugiyama defeated Cara Black / Elena Likhovtseva, 6–0, 1–6, 6–1
• It was Halard-Decugis' 1st and only career Grand Slam doubles title.
• It was Sugiyama's 1st career Grand Slam doubles title and her 1st and only title at the US Open.
See main article: 2000 US Open – Mixed doubles. 
Arantxa Sánchez Vicario / Jared Palmer defeated Anna Kournikova / Max Mirnyi, 6–4, 6–3
• It was Sánchez Vicario's 4th and last career Grand Slam mixed doubles title and her 1st and only title at the US Open.
• It was Palmer's 2nd and last career Grand Slam mixed doubles title and his 1st and only title at the US Open.
Andy Roddick[2] defeated Robby Ginepri, 6–1, 6–3
María Emilia Salerni defeated 
Tatiana Perebiynis, 6–3, 6–4
Lee Childs / James Nelson defeated Tres Davis / Robby Ginepri, 6–2, 6–4
Gisela Dulko / María Emilia Salerni defeated
Anikó Kapros / Christina Wheeler, 3–6, 6–2, 6–2
| width=200 colspan=2 bgcolor=#dfe2e9 | Event | width=80 bgcolor=lime | W | width=85 bgcolor=#D8BFD8 | F | width=85 bgcolor=#FFFF00 | SF | width=85 bgcolor=#ffebcd | QF | width=85 bgcolor=#afeeee | 4R | width=85 bgcolor=#afeeee | 3R | width=85 bgcolor=#afeeee | 2R | width=85 bgcolor=#afeeee | 1R |
| Singles [3] | Men | $800,000 | $425,000 | $220,000 | $110,000 | $55,000 | $35,000 | $20,000 | $10,000 | ||||||||
| Women | $800,000 | $425,000 | $220,000 | $110,000 | $55,000 | $35,000 | $20,000 | $10,000 | |||||||||