| Year: | 2000 |
| Team: | TCU Horned Frogs |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Coachrank: | 18 |
| Aprank: | 21 |
| Record: | 10–2 |
| Conf Record: | 7–1 |
| Hc Year: | 3rd |
| Hc Games2: | bowl game |
| Cooff Coach1: | Mike Schultz |
| Cooc1 Year: | 3rd |
| Cooff Coach2: | Les Koenning |
| Cooc2 Year: | 1st |
| Dc Year: | 3rd |
| Stadium: | Amon G. Carter Stadium (Capacity: 44,008) |
| Champion: | WAC co-champion |
| Bowl Result: | L 21–28 vs. Southern Mississippi |
The 2000 TCU Horned Frogs football team represented Texas Christian University (TCU) in the 2000 NCAA Division I-A football season. The team was led by head coach Dennis Franchione throughout the regular season. Gary Patterson took over as interim head coach in December. TCU played their home games in Amon G. Carter Stadium, which is located on campus in Fort Worth, Texas. The Horned Frogs finished the 10–2 and 7–1 in conference play to share the Western Athletic Conference championship with UTEP.
See also: 2000 NCAA Division I-A football rankings.
| Player | Position | Round | Pick | NFL club |
| Running Back | 1 | 5 | San Diego Chargers | |
| Defensive End | 2 | 46 | Buffalo Bills | |
| Running Back | 4 | 108 | Kansas City Chiefs | |
| Curtis Fuller | Defensive Back | 4 | 127 | Seattle Seahawks |
| Defensive Tackle | 4 | 130 | Minnesota Vikings | |
| Wide Receiver | 4 | 131 | Minnesota Vikings | |