| Year: | 2000 |
| Team: | South Florida Bulls |
| Sport: | football |
| Conference: | Independent |
| Record: | 7–4 |
| Head Coach: | Jim Leavitt |
| Hc Year: | 4th |
| Off Coach: | Mike Canales |
| Oc Year: | 4th |
| Def Coach: | Rick Kravitz |
| Dc Year: | 4th |
| Stadium: | Raymond James Stadium |
The 2000 South Florida Bulls football team represented the University of South Florida (USF) as an independent during the 2000 NCAA Division I-AA football season. Led by fourth-year head coach Jim Leavitt, the Bulls compiled a record of 7–4. South Florida played home games at Raymond James Stadium in Tampa, Florida.
See main article: 2001 NFL draft. The following Bulls were selected in the National Football League draft following the season.[1]
| 4 | 96 | Kenyatta Jones | Defensive tackle | New England Patriots | |
| 4 | 97 | Anthony Henry | Defensive back | Cleveland Browns | |
| 4 | 98 | Bill Gramatica | Kicker | Arizona Cardinals |