| Year: | 2000 |
| Team: | SMU Mustangs |
| Sport: | football |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 3–9 |
| Conf Record: | 2–6 |
| Head Coach: | Mike Cavan |
| Hc Year: | 4th |
| Off Coach: | Larry Kueck |
| Oc Year: | 2nd |
| Off Scheme: | Spread option |
| Def Coach: | Eric Schumann |
| Dc Year: | 4th |
| Def Scheme: | 4–3 |
The 2000 SMU Mustangs football team represented Southern Methodist University (SMU) as a member the Western Athletic Conference (WAC) during the 2000 NCAA Division I-A football season. Led by fourth-year head coach Mike Cavan, the Mustangs compiled an overall record of 3–9 with a mark of 2–6 in conference play, tying for sixth place in the WAC.