| Year: | 2000 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southeastern Conference |
| Division: | Western Division |
| Short Conf: | SEC |
| Record: | 7–5 |
| Conf Record: | 4–4 |
| Head Coach: | David Cutcliffe |
| Hc Year: | 2nd |
| Off Coach: | John Latina |
| Oc Year: | 1st |
| Def Coach: | Art Kaufman |
| Dc Year: | 6th |
| Stadium: | Vaught–Hemingway Stadium |
| Bowl: | Music City Bowl |
| Bowl Result: | L 38–49 vs. West Virginia |
The 2000 Ole Miss Rebels football team represented the University of Mississippi during the 2000 NCAA Division I-A football season. They participated as members of the Southeastern Conference in the West Division. Coached by David Cutcliffe, the Rebels played their home games at Vaught–Hemingway Stadium in Oxford, Mississippi.
See also: 2000 NCAA Division I-A football rankings.