| Year: | 2000 |
| Team: | Grambling State Tigers |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Short Conf: | SWAC |
| Division: | West Division |
| Tsnrank: | 13 |
| Record: | 10–2 |
| Conf Record: | 6–1 |
| Head Coach: | Doug Williams |
| Hc Year: | 3rd |
| Off Coach: | Melvin Spears |
| Oc Year: | 3rd |
| Stadium: | Eddie G. Robinson Memorial Stadium |
| Champion: | Black college football national champion SWAC champion SWAC West Division champion |
| Conf Champ: | SWAC Championship Game |
| Conf Champ Result: | W 14–6 vs. Alabama A&M |
The 2000 Grambling State Tigers football team represented Grambling State University as a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2000 NCAA Division I-AA football season. Led by third-year head coach Doug Williams, the Tigers compiled an overall record of 10–2 with a mark of 6–1 in conference play, winning the SWAC West Division title. Grambling State beat Alabama A&M in the SWAC Championship Game to the conference title. The team was also recognized as a black college football national champion. The Tigers offense scored 300 points while the defense allowed 207 points on the season.[1] Grambling State played home games at Eddie G. Robinson Memorial Stadium in Grambling, Louisiana.
| Player | Position | Round | Pick | NFL team |
| Scotty Anderson | Wide receiver | 5 | 148 | Detroit Lions |