The 2000 Edmonton Eskimos finished second in the West Division with a 10–8–0–1 record, but lost the West Semi-Final to the eventual champion BC Lions.
| Round | Pick | Player | Position | School | |
|---|---|---|---|---|---|
| 1 | 3 | Tim Bakker | C | Western Ontario | |
| 2 | 9 | Rob Harrod | WR | Ottawa | |
| 2 | 10 | Craig Carr | RB | Manitoba | |
| 3 | 17 | George Hudson | G | New Mexico State | |
| 5 | 33 | Bob Vickers | T | Wilfrid Laurier | |
| 6 | 41 | Yves Dossous | LB | Kent State |
| Week | Date | Opponent | Score | Result | Attendance | Record | |
|---|---|---|---|---|---|---|---|
| A | June 21 | vs British Columbia Lions | 26–21 | L | 30155 | 0–1 | |
| B | June 27 | at Saskatchewan Roughriders | 38–23 | W | 22101 | 1–1 |
| Team | GP | W | L | T | OTL | PF | PA | Pts | |
|---|---|---|---|---|---|---|---|---|---|
| Calgary Stampeders | 18 | 12 | 5 | 1 | 0 | 604 | 495 | 25 | |
| Edmonton Eskimos | 18 | 10 | 8 | 0 | 1 | 527 | 520 | 21 | |
| BC Lions | 18 | 8 | 10 | 0 | 1 | 513 | 529 | 17 | |
| Saskatchewan Roughriders | 18 | 5 | 12 | 1 | 0 | 516 | 626 | 11 |
| Week | Date | Opponent | Score | Result | Attendance | Record | Streak | |
|---|---|---|---|---|---|---|---|---|
| 1 | July 5 | at Calgary Stampeders | 44–22 | L | 34383 | 0–1 | L1 | |
| 2 | July 14 | vs Hamilton Tiger-Cats | 28–21 | L | 30033 | 0–2 | L2 | |
| 3 | July 21 | vs Winnipeg Blue Bombers | 51–49 | W | 27596 | 1–2 | W1 | |
| 4 | July 27 | at British Columbia Lions | 29–13 | W | 23714 | 2–2 | W2 | |
| 5 | August 4 | at Hamilton Tiger-Cats | 16–10 | W | 21333 | 3–2 | W3 | |
| 6 | August 11 | vs Montreal Alouettes | 29–7 | W | 31472 | 4–2 | W4 | |
| 7 | August 18 | at Saskatchewan Roughriders | 28–22 | W | 21707 | 5–2 | W5 | |
| 8 | August 25 | vs Saskatchewan Roughriders | 30–20 | L | 36813 | 5–3 | L1 | |
| 9 | September 4 | at Calgary Stampeders | 30–18 | W | 35967 | 6–3 | W1 | |
| 10 | September 8 | vs Calgary Stampeders | 31–10 | W | 53248* | 7–3 | W2 | |
| 11 | September 16 | at British Columbia Lions | 26–14 | L | 20234 | 7–4 | L1 | |
| 12 | September 22 | vs Toronto Argonauts | 34-21 | L | 28649 | 7–5 | L2 | |
| 13 | October 4 | vs British Columbia Lions | 49–42 | W | 28865 | 8–5 | W1 | |
| 14 | October 9 | at Montreal Alouettes | 45–15 | L | 19461 | 8–6 | L1 | |
| 15 | October 15 | vs Calgary Stampeders | 33–13 | W | 34318 | 9–6 | W1 | |
| 16 | October 21 | at Toronto Argonauts | 48–28 | W | 18129 | 10–6 | W2 | |
| 17 | October 28 | vs Saskatchewan Roughriders | 54–52 | OTL | 34218 | 10–7–0–1 | L1 | |
| 18 | November 3 | at Winnipeg Blue Bombers | 30–18 | L | 25537 | 10–8–0–1 | L2 |
Western Semi-Final
| Team | Q1 | Q2 | Q3 | Q4 | Total | |
|---|---|---|---|---|---|---|
| Edmonton Eskimos | 3 | 8 | 3 | 18 | 32 | |
| BC Lions | 14 | 3 | 14 | 3 | 34 |