| Tourney Name: | CAF Cup |
| Year: | 2000 |
| Dates: | 31 January 2001 – 1 December 2001 |
| Num Teams: | 33 |
| Champion Other: |  JS Kabylie |
| Count: | 1 |
| Second Other: |  Ismaily |
| Matches: | 57 |
| Prevseason: | 1999 |
| Nextseason: | 2001 |
The 2000 CAF Cup was the 9th edition of the CAF Cup, the African continental club competition for runners up of the respective domestic leagues. It was won by Algerian team JS Kabylie who beat Ismaily SC of Egypt on the away goals rule in the final, after they finished level on aggregate 1-1.
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|}1 AC Semassi, Aslad Moundou and Saint Anthony's withdrew before first leg
|}1 Hay El Arab withdrew after 1st leg
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Ismaily won 7-0 on aggregate and advanced to the final.----JS Kabylie won 2-1 on aggregate and advanced to the final.
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1-1 on aggregate, JS Kabylie won on away goals rule