| Team: | Buffalo Destroyers |
| Year: | 2000 |
| Record: | 5–9 |
| Division Place: | 3rd |
| Coach: | Dave Whinham (fired Week 4, 0–4 record) Ray Bentley (5–5 record) |
| Stadium: | HSBC Arena |
| Playoffs: | Lost 1st round (vs. Rattlers) 34–41 |
| Shortnavlink: | Destroyers seasons |
The 2000 Buffalo Destroyers season was the 2nd season for the franchise and the 2nd in Buffalo, New York. They finished with a 5–9 record and qualified for the playoffs for the first time in franchise history. The Destroyers lost to the Arizona Rattlers, 41–34 in the first round.
Dave Whinham began the season at head coach for the Destroyers, but was fired after starting the season 0–4. Former Buffalo Bills linebacker Ray Bentley was hired to coach the team for the remainder of the season and led the Destroyers to a 5–5 finish and a playoff berth.
| Week | Date | Opponent | Home/Away | Result | |
|---|---|---|---|---|---|
| 1 | March 27 | Orlando Predators | Home | L 30–46[1] | |
| 2 | March 31 | Iowa Barnstormers | Away | L 50–53[2] |
| Week | Date | Opponent | Home/Away | Result | |
|---|---|---|---|---|---|
| 1 | April 15 | Oklahoma Wranglers | Away | L 51–62[3] | |
| 2 | April 22 | Iowa Barnstormers | Home | L 35–56[4] | |
| 3 | April 29 | New England Sea Wolves | Away | L 31–58[5] | |
| 4 | May 6 | New Jersey Red Dogs | Home | L 42–62[6] | |
| 5 | May 12 | Albany Firebirds | Away | L 23–75[7] | |
| 6 | May 19 | San Jose SaberCats | Home | L 35–61[8] | |
| 7 | May 26 | New England Sea Wolves | Home | L 34–37[9] | |
| 8 | June 2 | Nashville Kats | Away | L 28–42[10] | |
| 9 | June 10 | Albany Firebirds | Home | W 51–48 (OT)[11] | |
| 10 | June 17 | Houston Thunderbears | Away | W 55–44[12] | |
| 11 | June 25 | New Jersey Red Dogs | Away | W 79–54[13] | |
| 12 | June 29 | Florida Bobcats | Home | W 36–33 (OT)[14] | |
| 13 | Bye Week | ||||
| 14 | July 14 | Los Angeles Avengers | Home | W 60–52[15] | |
| 15 | July 22 | San Jose SaberCats | Away | L 54–83[16] |