| Year: | 2000 |
| Team: | Buffalo Bulls |
| Sport: | football |
| Conference: | Mid-American Conference |
| Division: | East Division |
| Short Conf: | MAC |
| Record: | 2–9 |
| Conf Record: | 2–6 |
| Head Coach: | Craig Cirbus |
| Hc Year: | 6th |
| Def Coach: | Joe Reich |
| Dc Year: | 4th |
| Captain: | Brandon Shaughnessy, Gabe Kogler, Tory Smith, Chris Gray, Marcus Cole |
| Stadium: | University at Buffalo Stadium |
The 2000 Buffalo Bulls football team represented the University at Buffalo in the 2000 NCAA Division I-A football season. The Bulls offense scored 177 points while the defense allowed 452 points.