| Club: | RCD Espanyol |
| Season: | 2000–01 |
| Chrtitle: | President |
| Chairman: | Daniel Sánchez Llibre |
| Mgrtitle: | Head coach |
| Manager: | Paco Flores |
| Stadium: | Estadi Olímpic de Montjuïc |
| League: | La Liga |
| League Result: | 9th |
| Cup1: | Copa del Rey |
| Cup1 Result: | Quarter-finals |
| Cup2: | Supercopa de España |
| Cup2 Result: | Runners-up |
| Cup3: | UEFA Cup |
| Cup3 Result: | Third round |
| League Topscorer: | Raúl Tamudo (11) |
| Season Topscorer: | Raúl Tamudo (13) |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
The 2000–01 season was the 66th season in the existence of RCD Espanyol and the club's seventh consecutive season in the top flight of Spanish football. In addition to the domestic league, Espanyol participated in this season's edition of the Copa del Rey, Supercopa de España, and UEFA Cup.
Updated on 18 January 2023[1] [2] [3] [4] |-|colspan="12"|Players who have left the club after the start of the season: