| Competition: | Liga Nacional |
| Season: | 2000–01 |
| Winners: | Apertura: Olimpia Clausura: Platense |
| Relegated: | Broncos |
| Continentalcup1: | Champions' Cup |
| Continentalcup1 Qualifiers: | Olimpia Platense |
| League Topscorer: | Apertura: Marcelo Verón (13) Clausura: Pompilio Cacho (13) |
| Total Goals: | 514 |
| Matches: | 205 |
| Biggest Home Win: | Victoria 4–0 Broncos (8 November 2000) Platense 4–0 Universidad (15 December 2000) Deportes Savio 4–0 Vida (13 January 2001) |
| Biggest Away Win: | Broncos 0–6 Olimpia (18 October 2000) |
| Highest Scoring: | Universidad 2–5 Olimpia (22 November 2000) Vida 3–4 Olimpia (25 March 2001) |
| Longest Unbeaten: | Olimpia (10) |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
| Updated: | 22 July 2001 |
The 2000–01 Honduran Liga Nacional was the 36th season in the history of the Honduran top division; this was the third tournament under the Apertura and Clausura format; C.D. Olimpia managed to beat C.D. Platense in the Apertura Final and obtained its 15th league title; in the Clausura C.D. Platense took revenge over C.D. Olimpia and won its 2nd title. The league games started 30 September 2000 and ended on 22 July 2001. [1]
The Apertura tournament was the first half of the 2000–01 season in the Honduran football; Club Deportivo Olimpia set a record of 10 wins in a row, the first nine composed a whole round-robin. In the Final match Olimpia conquered its 15th title after defeating C.D. Platense 2–1 on aggregated score.
As of 13 January 2001
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13 goals
8 goals
6 goals
1 goal
In the Clausura tournament of the 2000–01 season; C.D. Platense took revenge on C.D. Olimpia and achieved its second championship in its history. On the other hand, C.D. Broncos although they finished fifth in the Regular season, they were not allow to participate in the Hexagonal, due to their condition of relegated team; C.D. Motagua replaced them instead.
As of 17 June 2001
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| GK | – | Víctor Coello | ||
| RB | 10 | Edgar Álvarez | ||
| CB | 4 |  José Anthony Torres | ||
| CB | 3 | Ángel Hill | ||
| LB | 7 | Rony Morales | ||
| CM | – | Marco Mejía | ||
| CM | – | |||
| CM | – | Fabricio Pérez | ||
| LF | 11 | |||
| CF | 29 |  Marcelo Verón | ||
| RF | 8 | |||
| Substitutions: | ||||
| CM | – | |||
| CB | – | |||
| Manager: | ||||
| Alberto Romero | ||||
| GK | 27 | Donaldo González | ||
| RB | 3 | Gerson Vásquez | ||
| CB | 6 | Fabio Ulloa | ||
| CB | 15 | Robert Lima | ||
| LB | – | Arnold Cruz | ||
| DM | 5 | Merlyn Membreño | ||
| CM | 8 | |||
| CM | – | Christian Santamaría | ||
| AM | 18 | Danilo Tosello | ||
| CF | 19 | |||
| CF | 24 |  Marcelo Ferreira | ||
| CF | 22 | |||
| Substitutions: | ||||
| ST | 25 | |||
| CM | – | |||
| Manager: | ||||
| Edwin Pavón | ||||
| GK | 27 | Donaldo González | |
| RB | 3 | Gerson Vásquez | |
| CB | 15 | Robert Lima | |
| CB | 6 | Fabio Ulloa | |
| LB | 5 | Merlyn Membreño | |
| CM | 8 | José Pineda | |
| CM | – | Elmer Marín | |
| CM | – | Christian Santamaría | |
| AM | 18 | Danilo Tosello | |
| CF | 19 | Denilson Costa | |
| CF | 25 | Elvis Scott | |
| CF | 23 | Gustavo Fuentes | |
| Substitutions: | |||
| – | – | – | |
| – | – | – | |
| – | – | – | |
| Manager: | |||
| Edwin Pavón | |||
| GK | 1 | Ricardo James | ||
| RB | 10 | Edgar Álvarez | ||
| CB | 4 | José Torres | ||
| CB | – | Mario Beata | ||
| LB | – | Rony Morales | ||
| CM | – | Marco Mejía | ||
| CM | – | Walter Hernández | ||
| RM | – | Fabricio Pérez | ||
| LM | – | Óscar Bonilla | ||
| RS | 29 | Marcelo Verón | ||
| LS | 8 | José Pacini | ||
| Substitutions: | ||||
| CB | – | |||
| RW | 11 | |||
| Manager: | ||||
| Alberto Romero | ||||
13 goals
10 goals
8 goals
7 goals
5 goals
2 goals
Relegation was determined by the aggregated table of both Apertura and Clausura tournaments.