| Competition: | Alpha Ethniki |
| Season: | 2000–01 |
| Winners: | Olympiacos 30th Greek title |
| Relegated: | PAS Giannina Paniliakos Kalamata Athinaikos |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Olympiacos Panathinaikos |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | AEK Athens PAOK |
| League Topscorer: | Alexis Alexandris (20 goals) |
| Matches: | 240 |
| Total Goals: | 717 |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
The 2000–01 Alpha Ethniki was the 65th season of the highest football league of Greece. The season began on 16 September 2000 and ended on 27 May 2001. Olympiacos won their fifth consecutive and 30th Greek title.
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Source: Galanis Sports Data
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Alexis Alexandris | Olympiacos | 20 |
| 2 |  Michalis Konstantinou | Iraklis | 18 |
| 3 | Demis Nikolaidis | AEK Athens | 15 |
| 4 | Vasilios Tsiartas | AEK Athens | 14 |
| Predrag Đorđević | Olympiacos | ||
| 6 | Ilias Solakis | Panachaiki | 13 |
 Krzysztof Warzycha | Panathinaikos | ||
| 8 | Goran Vlaović | Panathinaikos | 12 |
| 9 | Giorgos Kontopoulos | Ethnikos Asteras | 11 |
| Nikos Liberopoulos | Panathinaikos | ||
| Stelios Giannakopoulos | Olympiacos |
Annual awards were announced on 8 October 2001.[1]
| Award | Winner | Club | |
|---|---|---|---|
| Greek Player of the Season | Alexis Alexandris | Olympiacos | |
| Foreign Player of the Season |  Predrag Đorđević | Olympiacos | |
| Young Player of the Season | Giourkas Seitaridis | Panathinaikos | |
| Goalkeeper of the Season | Vangelis Pourliotopoulos | Panionios | |
| Fair Play of the Season | Angelos Anastasiadis | Panathinaikos | |
| Golden Boot | Alexis Alexandris | Olympiacos | |
| Manager of the Season |  Dušan Bajević | PAOK |
