| Competition: | Slovenian PrvaLiga |
| Season: | 2000–01 |
| Winners: | Maribor (5th title) |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Maribor |
| Continentalcup2: | UEFA Cup |
| Continentalcup3: | Intertoto Cup |
| Continentalcup3 Qualifiers: | Celje |
| League Topscorer: | Damir Pekič (23 goals) |
| Biggest Home Win: | Olimpija 6–0 Tabor |
| Biggest Away Win: | Tabor 0–5 Primorje |
| Highest Scoring: | Domžale 2–6 Rudar |
| Matches: | 198 |
| Total Goals: | 592 |
| Longest Wins: | 5 games Maribor |
| Longest Unbeaten: | 10 games Maribor |
| Longest Winless: | 8 games Tabor Rudar |
| Longest Losses: | 6 games Dravograd |
| Highest Attendance: | 8,000 Olimpija 1–1 Maribor |
| Lowest Attendance: | 200 Rudar 2–0 Primorje |
| Attendance: | 234,780 |
| Average Attendance: | 1,185 |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
The 2000–01 Slovenian PrvaLiga season started on 21 July 2000 and ended on 27 May 2001. Each team played a total of 33 matches.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Damir Pekič | Maribor | 23 |
| 2 | Sebastjan Cimirotič | Olimpija | 19 |
| 3 | Ermin Rakovič | Olimpija | 16 |
| 4 |  Goran Gutalj | Gorica | 15 |
| 5 | Vanja Starčević | Primorje | 13 |
| 6 | Slavko Komar | Domžale | 12 |
| Saša Jakomin | Koper | ||
| Anton Žlogar | Gorica | ||
| 9 | Patrik Ipavec | Gorica | 11 |
| 10 | Samo Vidovič | Dravograd | 10 |
| Marko Vogrič | Primorje |