| Manager: | Paul Jewell (until 12 February) Peter Shreeves (from 12 February) |
| Mgrtitle: | Manager |
| Chairman: | Howard Culley (succeeded by Geoff Hulley) |
| Chrtitle: | Chairman |
| League Result: | 17th |
| Cup1 Result: | Fourth round |
| Cup2 Result: | Quarter-final |
| League Topscorer: | Sibon (13) |
| Season Topscorer: | Sibon (15) |
| Highest Attendance: | 38,433 (vs. Sheffield United Division One) |
| Lowest Attendance: | 4,773 (vs. Oldham Athletic League Cup) |
| Average Attendance: | 19,268 (League games only) |
| Nextseason: | 2001–02 |
During the 2000–01 English football season, Sheffield Wednesday F.C. competed in the Football League First Division.
Peter Shreeves remained at Sheffield Wednesday for the 2000–01 season as assistant to their new manager Paul Jewell. But Jewell was unable to mount a promotion challenge and he was sacked the following February with the Owls hovering just above the Division One relegation zone. Shreeves was given a permanent contract to take charge of the first team and he guided them to a 17th-place finish.
Sheffield Wednesday's score comes first[1]
| Win | Draw | Loss |
| Date | Opponent | Venue | Result | Attendance | Scorers | |
|---|---|---|---|---|---|---|
| 13 August 2000 | Wolverhampton Wanderers | A | 1–1 | 19,086 | Booth | |
| 19 August 2000 | Huddersfield Town | H | 2–3 | 22,704 | Booth, Hinchcliffe (pen) | |
| 26 August 2000 | Grimsby Town | A | 1–0 | 7,755 | Di Piedi | |
| 28 August 2000 | Blackburn Rovers | H | 1–1 | 15,646 | Westwood | |
| 9 September 2000 | Wimbledon | H | 0–5 | 15,856 | ||
| 13 September 2000 | Nottingham Forest | H | 0–1 | 15,700 | ||
| 16 September 2000 | Tranmere Rovers | A | 0–2 | 9,352 | ||
| 23 September 2000 | Preston North End | H | 1–3 | 17,379 | Morrison | |
| 30 September 2000 | Gillingham | A | 0–2 | 9,099 | ||
| 8 October 2000 | West Bromwich Albion | H | 1–2 | 15,338 | Morrison | |
| 14 October 2000 | Portsmouth | A | 1–2 | 13,376 | Morrison | |
| 17 October 2000 | Burnley | A | 0–1 | 16,372 | ||
| 22 October 2000 | Birmingham City | H | 1–0 | 14,695 | Harkness | |
| 25 October 2000 | Queens Park Rangers | A | 2–1 | 10,353 | Cooke, Quinn | |
| 28 October 2000 | Fulham | H | 3–3 | 17,559 | Sibon, Morrison, Westwood | |
| 4 November 2000 | Crystal Palace | A | 1–4 | 15,333 | Sibon (pen) | |
| 7 November 2000 | Watford | A | 3–1 | 11,166 | Jobson, Crane, Quinn | |
| 11 November 2000 | Norwich City | H | 3–2 | 16,956 | Hinchcliffe (pen), Crane, Di Piedi | |
| 18 November 2000 | Barnsley | A | 0–1 | 19,989 | ||
| 25 November 2000 | Crewe Alexandra | A | 0–1 | 7,103 | ||
| 2 December 2000 | Queens Park Rangers | H | 5–2 | 21,782 | Sibon (3), Morrison, Ekoku | |
| 9 December 2000 | Stockport County | H | 2–4 | 16,337 | Morrison, Ekoku | |
| 16 December 2000 | Sheffield United | A | 1–1 | 25,156 | Hendon | |
| 23 December 2000 | Wolverhampton Wanderers | H | 0–1 | 17,787 | ||
| 26 December 2000 | Bolton Wanderers | A | 0–2 | 21,316 | ||
| 30 December 2000 | Huddersfield Town | A | 0–0 | 18,931 | ||
| 1 January 2001 | Grimsby Town | H | 1–0 | 17,004 | Sibon | |
| 13 January 2001 | Blackburn Rovers | A | 0–2 | 19,308 | ||
| 20 January 2001 | Bolton Wanderers | H | 0–3 | 17,638 | ||
| 3 February 2001 | Watford | H | 2–3 | 16,134 | Sibon, Ekoku | |
| 10 February 2001 | Wimbledon | A | 1–4 | 6,741 | Ekoku | |
| 13 February 2001 | Tranmere Rovers | H | 1–0 | 15,444 | Ekoku | |
| 21 February 2001 | Nottingham Forest | A | 1–0 | 23,266 | Sibon | |
| 24 February 2001 | Preston North End | A | 0–2 | 14,379 | ||
| 3 March 2001 | Gillingham | H | 2–1 | 18,702 | Ekoku, Di Piedi | |
| 7 March 2001 | Portsmouth | H | 0–0 | 20,503 | ||
| 10 March 2001 | West Bromwich Albion | A | 2–1 | 18,662 | Soltvedt, Booth | |
| 17 March 2001 | Burnley | H | 2–0 | 20,184 | Hendon, Sibon (pen) | |
| 24 March 2001 | Birmingham City | A | 2–1 | 19,733 | De Bilde, Di Piedi | |
| 1 April 2001 | Sheffield United | H | 1–2 | 38,433 | Sibon | |
| 7 April 2001 | Stockport County | A | 1–2 | 9,666 | De Bilde | |
| 14 April 2001 | Crystal Palace | H | 4–1 | 19,877 | Ekoku, De Bilde, Sibon, Ripley | |
| 16 April 2001 | Fulham | A | 1–1 | 17,500 | Sibon | |
| 21 April 2001 | Barnsley | H | 2–1 | 23,498 | Sibon, Donnelly | |
| 28 April 2001 | Norwich City | A | 0–1 | 21,241 | ||
| 6 May 2001 | Crewe Alexandra | H | 0–0 | 28,007 |
See main article: 2000–01 FA Cup.
| R3 | 6 January 2001 | Norwich City | H | 2–1 | 15,971 | Hamshaw, Sibon | |
| R4 | 27 January 2001 | Southampton | A | 1–3 | 15,251 | Booth |
See main article: 2000–01 Football League Cup.
| R2 1st Leg | 19 September 2000 | Oldham Athletic | A | 3–1 | 3,213 | Morrison, De Bilde, Westwood | |
| R2 2nd Leg | 27 September 2000 | Oldham Athletic | H | 5–1 | 4,773 | Hamshaw, Westwood, Di Piedi, Sibon, Quinn | |
| R3 | 1 November 2000 | Sheffield United | H | 2–1 | 32,283 | Ekoku (2) | |
| R4 | 29 November 2000 | West Ham United | A | 2–1 | 20,853 | Morrison, Westwood | |
| QF | 12 December 2000 | Birmingham City | A | 0–2 | 22,911 |