The 2000–01 QSPHL season was the fifth season of the Quebec Semi-Pro Hockey League, a minor professional league in the Canadian province of Quebec. 14 teams participated in the regular season, and the Mission de Joliette won the league title.
| Division Est | GP | W | L | OTL | SOL | GF | GA | Pts | |
|---|---|---|---|---|---|---|---|---|---|
| 44 | 32 | 9 | 1 | 2 | 229 | 139 | 67 | ||
| 44 | 29 | 8 | 2 | 5 | 233 | 164 | 65 | ||
| 44 | 24 | 15 | 2 | 3 | 222 | 231 | 53 | ||
| 44 | 23 | 17 | 1 | 3 | 173 | 162 | 50 | ||
| 44 | 22 | 18 | 1 | 3 | 228 | 208 | 48 | ||
| 44 | 16 | 21 | 4 | 3 | 176 | 228 | 39 | ||
| 44 | 15 | 24 | 3 | 2 | 186 | 248 | 35 |
| Division Ouest | GP | W | L | OTL | SOL | GF | GA | Pts | |
|---|---|---|---|---|---|---|---|---|---|
| 44 | 28 | 10 | 1 | 5 | 238 | 170 | 62 | ||
| 44 | 26 | 14 | 1 | 3 | 192 | 178 | 56 | ||
| 44 | 25 | 16 | 1 | 2 | 206 | 190 | 53 | ||
| 44 | 20 | 22 | 1 | 1 | 181 | 179 | 42 | ||
| 44 | 18 | 24 | 1 | 1 | 180 | 220 | 38 | ||
| 44 | 16 | 24 | 3 | 1 | 162 | 219 | 36 | ||
| 44 | 13 | 29 | 1 | 1 | 164 | 230 | 28 |