| Club: | PSV Eindhoven |
| Season: | 2000–01 |
| Manager: | Eric Gerets |
| Mgrtitle: | Head coach |
| Stadium: | Philips Stadion |
| League: | Eredivisie |
| League Result: | 1st |
| Cup1: | KNVB Cup |
| Cup1 Result: | Runners-up |
| Cup2: | Johan Cruyff Shield |
| Cup2 Result: | Winners |
| Cup3: | Champions League |
| Cup3 Result: | Group stage |
| Cup4: | UEFA Cup |
| Cup4 Result: | Quarter-finals |
| League Topscorer: | Mateja Kežman (24) |
| Season Topscorer: | Mateja Kežman (31) |
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| Prevseason: | 1999–00 |
| Nextseason: | 2001–02 |
During the 2000–01 Dutch football season, PSV Eindhoven competed in the Eredivisie.
PSV claimed the Eredivisie title for the second year in a row with 83 points in total. The margin to the second-placed Feyenoord was 17 points. In the KNVB Cup, the team lost in the final against Twente. In the Champions League, the team was knocked out in the group stage, finishing third behind Anderlecht and Manchester United. In the UEFA Cup (now known as Europa League), the team was knocked out in the quarter-finals against Kaiserslautern with two 1-0 defeats.
PSV's kit was manufactured by Nike and sponsored by Philips
Squad at end of season
See main article: 2000–01 Eredivisie.