| Club: | Olympiacos |
| Season: | 2000–01 |
| Manager: | Takis Lemonis |
| Chairman: | Sokratis Kokkalis |
| Stadium: | Athens Olympic Stadium |
| League: | Alpha Ethniki |
| League Result: | Winners |
| Cup1: | Greek Cup |
| Cup1 Result: | Runner-up |
| Cup2: | Champions League |
| Cup2 Result: | Group Stage |
| Cup3: | UEFA Cup |
| Cup3 Result: | Third round |
| League Topscorer: | Alexis Alexandris (20) |
| Season Topscorer: | Alexis Alexandris (31) |
| Pattern La1: | _olympiacosfc2000h |
| Pattern B1: | _olympiacosfc2000h |
| Pattern Ra1: | _olympiacosfc2000h |
| Pattern So1: | _olympiacosfc2000h |
| Leftarm1: | FFFFFF |
| Body1: | FFFFFF |
| Rightarm1: | FFFFFF |
| Shorts1: | FFFFFF |
| Socks1: | 000000 |
| Pattern La2: | _thinblackborder |
| Pattern B2: | _olympiacosfc2000a |
| Pattern Ra2: | _thinblackborder |
| Pattern So2: | _olympiacosfc2000h |
| Leftarm2: | AFB3B4 |
| Body2: | AFB3B4 |
| Rightarm2: | AFB3B4 |
| Shorts2: | 000000 |
| Socks2: | 000000 |
| Pattern B3: | _olympiacosfc2000t |
| Leftarm3: | F20D2F |
| Body3: | F20D2F |
| Rightarm3: | F20D2F |
| Shorts3: | F20D2F |
| Socks3: | F20D2F |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
The 2000–01 season was Olympiacos's 42nd consecutive season in the Alpha Ethniki and their 75th year in existence. The club were played their 4th consecutive season in the UEFA Champions League. In the beginning of the summertime Olympiacos named Greek Takis Lemonis coach.
See main article: 2000–01 Alpha Ethniki.
See main article: 2000–01 Greek Football Cup.
See main article: 2000–01 UEFA Champions League.
All times at CET
See main article: 2000–01 UEFA Cup.
All times at CET
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