| Club: | Lille |
| Season: | 2000–01 |
| Chrtitle: | President |
| Chairman: | Luc Dayan Francis Graille |
| Mgrtitle: | Head coach |
| Manager: | Vahid Halilhodžić |
| Stadium: | Stade Grimonprez-Jooris |
| League: | Division 1 |
| League Result: | 3rd |
| Cup1: | Coupe de France |
| Cup1 Result: | Round of 64 |
| Cup2: | Coupe de la Ligue |
| Cup2 Result: | Round of 32 |
| Average Attendance: | 16,793[1] |
| Leftarm1: | D8001D |
| Body1: | D8001D |
| Rightarm1: | D8001D |
| Shorts1: | 002B6D |
| Socks1: | 002B6D |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
| Socks2: | FFFFFF |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
The 2000–01 season was the 57th season in the existence of Lille OSC and the club's first season back in the top flight of French football. They participated in the Ligue 1, the Coupe de France and the Coupe de la Ligue.
See main article: 2000–01 French Division 1.