| Club: | 1. FC Kaiserslautern |
| Season: | 2000–01 |
| Manager: | Andreas Brehme |
| Stadium: | Fritz-Walter-Stadion |
| League: | Bundesliga |
| League Result: | 8th |
| Cup1: | DFB-Pokal |
| Cup1 Result: | Second round |
| Cup2: | DFB-Ligapokal |
| Cup2 Result: | Semi-finals |
| Cup3: | UEFA Cup |
| Cup3 Result: | Semi-finals |
| League Topscorer: | Miroslav Klose Vratislav Lokvenc (9 each) |
| Season Topscorer: | Vratislav Lokvenc (12 goals) |
| Prevseason: | 1999–2000 |
| Nextseason: | 2001–02 |
During the 2000–01 German football season, 1. FC Kaiserslautern competed in the Bundesliga.
Although Kaiserlautern recorded the same number of points as they had the previous season, they finished in 8th, three places lower. Greater success came in the UEFA Cup, as Kaiserlautern reached the semi-finals before being eliminated by Deportivo Alavés.
Squad at end of season[1]
See main article: article and 2000–01 Bundesliga.
See main article: article and 2000–01 DFB-Pokal.
See main article: article and 2000–01 UEFA Cup.
Kaiserslautern won 3–2 on aggregate.
Kaiserslautern win 5-4 on aggregate
Kaiserslautern win 3–1 on aggregate.
Kaiserslautern won 1–0 on aggregate.
Match interrupted for 16 minutes due to supporter disturbances.
Kaiserslautern won 2–0 on aggregate
Alavés won 9–2 on aggregate.