| Country: | Switzerland |
| Other Countries: | Liechtenstein |
| Confed: | UEFA |
| Founded: | (refounded) |
| Teams: | 64 (16 in 4 groups) |
| Promotion: | 1st League Classic |
| Relegation: | 2. Liga |
| Levels: | 5 |
| Domest Cup: | Swiss Cup |
| Champions: | Lancy FC FC Prishtina Bern FC Collina d'Oro SV Schaffhausen |
| Season: | 2023–24 |
| Current: | 2024–25 2. Liga Interregional |
2. Liga Interregional (2nd League Interregional in english) is the fifth tier of the Swiss football league system. From 2000 to 2012, it was the country's fourth level. From 2013, the league was demoted to fifth level. The division is split into 4 groups of 16 teams since 2023–24 season onwards, by geographical region.
2. Liga Interregional founded in 1924, refounded in 2000 the league between 1. Liga Classic and 2. Liga.
Since the creation in 1924, the league has been called :
Since the creation of Amateur League in 2000, the league has been called :
The 2022–23 season is the current season in the Swiss 2. Liga Interregional.
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| 2nd League / 2nd League Interregional champions | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Season | width=200 | Group 1 | width=200 | Group 2 | width=200 | Group 3 | width=200 | Group 4 | width=200 | Group 5 | width=200 | Group 6 |
| 2000–01 | FC Sion II | FC Baulmes | FC Basel II | FC Luzern II | FC Zürich II | Chur 97 | ||||||
| 2001–02 | ES FC Malley | FC Martigny-Sports | SC Zofingen | GC Biaschesi | FC Aarau II | FC Frauenfeld | ||||||
| 2002–03 | FC Sierre | BSC Young Boys II | SC Dornach | FC Seefeld | SC Cham | 5 groups (from 2002 until 2010) | ||||||
| 2003–04 | FC Lausanne-Sport | FC Alle | FC Brugg | FC Langenthal | FC Herisau | |||||||
| 2004–05 | FC Bernex-Confignon | SC Düdingen | Kickers Lucerne | SV Muttenz | FC Rapperswil-Jona | |||||||
| 2005–06 | FC Sion II | FC La Tour/Le Pâquier | FC Stabio | FC Olten | FC Gossau | |||||||
| 2006–07 | FC Savièse | SV Lyss | FC Schötz | BSC Old Boys | FC Küsnacht | |||||||
| 2007–08 | CS Chênois | FC Le Mont | FC Emmenbrücke | SV Höngg |  USV Eschen/Mauren | |||||||
| 2008–09 | Grand-Lancy FC | FC Breitenrain | FC Lugano II | FC Laufen | Chur 97 | |||||||
| 2009–10 | US Terre Sainte | FC Thun II | FC Aarau II | SC Dornach | SC Brühl | |||||||
| 2010–11 | Servette FC U21 | FC Bulle | FC Serrières | FC Muri | SV Höngg | FC Balzers | ||||||
| 2011–12 | US Terre Sainte | FC Köniz | FC Black Stars Basel | Zug 94 | FC Wettswil-Bonstetten | FC Kreuzlingen | ||||||
| 2012–13 | FC Azzurri 90 Lausanne | FC Bavois | Neuchâtel Xamax FCS | FC Sursee | FC Thalwil | Chur 97 | ||||||
| 2013–14 | FC Stade-Lausanne-Ouchy | Team Vaud U21 | FC Bern | AC Taverne | FC Dietikon | FC Seuzach | ||||||
| 2014–15 | Signal FC Bernex-Confignon | FC La Chaux-de-Fonds | FC Thun II | SC Buochs | FC United Zürich | FC Kosova | ||||||
| 2015–16 | FC Vevey Sports 1899 | FC La Sarraz-Eclépenz | FC Bassecourt | AC Bellinzona | FC Red Star Zürich | FC Seefeld | ||||||
| 2016–17 | Meyrin FC | FC Portalban/Gletterens | FC Langenthal | FC Kickers Luzern | SV Höngg | FC Kosova | ||||||
| 2017–18 | CS Chênois | FC Bulle | FC Biel-Bienne | FC Hergiswil | SC Zofingen | FC Linth 04 | ||||||
| 2018–19 | Olympique de Geneve FC | US Terre Sainte | SV Muttenz | FC Paradiso | FC Dietikon | FC Balzers | ||||||
| 2019–20 | Servette FC II | SC Düdingen | FC Moutier | FC Willisau | FC Muri | Chur 97 | ||||||
| 2020–21 | FC Monthey | FC La Sarraz-Eclépens | FC Thun II | Team Ticino | FC Freienbach | FC Uzwil | ||||||
| 2021–22 | FC Servette II | FC Portalban-Gletterens | SC Dornach | AC Taverne | FC Rotkreuz | FC Weesen | ||||||
| 2022–23 | Pully Football | Team Vaud U21 | FC Dietikon | FC Mendrisio | FC Balzers | 5 groups (for 2022–23) | ||||||
4 Groups from 2023 onwards:
| 2nd League Interregional champions | ||||||||
|---|---|---|---|---|---|---|---|---|
| Season | width=200 | Group 1 | width=200 | Group 2 | width=200 | Group 3 | width=200 | Group 4 |
| 2023–24 | Lancy FC | FC Prishtina Bern | FC Collina d'Oro | SV Schaffhausen | ||||
| 2024–25 | ||||||||