2-Polyprenyl-6-hydroxyphenol methylase explained
| 2-polyprenyl-6-hydroxyphenol methylase |
| Ec Number: | 2.1.1.222 |
2-polyprenyl-6-hydroxyphenol methylase (ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase.[1] [2] This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol
UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.
Notes and References
- Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF . Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis . The Journal of Biological Chemistry . 274 . 31 . 21665–72 . July 1999 . 10419476 . 10.1074/jbc.274.31.21665 . free .
- Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF . Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis . Biochemistry . 35 . 30 . 9797–806 . July 1996 . 8703953 . 10.1021/bi9602932 .
