2-phospho-L-lactate transferase explained

2-phospho-L-lactate transferase
Ec Number:	2.7.8.28

2-phospho-L-lactate transferase (LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin

\rightleftharpoons GMP + coenzyme F420-0

This enzyme is involved in the biosynthesis of coenzyme F420.

Notes and References

1. Graupner M, Xu H, White RH . Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii . Biochemistry . 41 . 11 . 3754–61 . March 2002 . 11888293 . 10.1021/bi011937v .
2. Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L . Molecular insights into the biosynthesis of the F420 coenzyme . The Journal of Biological Chemistry . 283 . 17 . 11832–40 . April 2008 . 18252724 . 2431047 . 10.1074/jbc.m710352200 . free .