2-oxoaldehyde dehydrogenase (NADP+) explained

2-oxoaldehyde dehydrogenase (NADP+)
Ec Number:	1.2.1.49
Cas Number:	83588-97-0
Go Code:	0047552

In enzymology, a 2-oxoaldehyde dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NADP⁺ + H₂O

\rightleftharpoons a 2-oxo acid + NADPH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NADP⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NADP+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NADP+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism.

References

• Ray M, Ray S . 1982 . On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase . J. Biol. Chem. . 257 . 10571 - 4 . 7107626 . 18 .
• Ray S, Ray M . 1982 . Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate . J. Biol. Chem. . 257 . 10566 - 70 . 7107625 . 18 .