2-oxoaldehyde dehydrogenase (NAD+) explained
| 2-oxoaldehyde dehydrogenase (NAD) |
| Ec Number: | 1.2.1.23 |
| Cas Number: | 37250-91-2 |
| Go Code: | 0047551 |
In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) is an enzyme that catalyzes the chemical reaction
a 2-oxoaldehyde + NAD+ + H2O
a 2-oxo acid + NADH + H
+The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+.
This enzyme participates in pyruvate metabolism.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase.Other names in common use include:
- alpha-ketoaldehyde dehydrogenase
- methylglyoxal dehydrogenase
- NAD+-linked alpha-ketoaldehyde dehydrogenase
- 2-ketoaldehyde dehydrogenase
- NAD+-dependent alpha-ketoaldehyde dehydrogenase
- 2-oxoaldehyde dehydrogenase (NAD+)
See also
References
- Monder C . 1967 . Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate . J. Biol. Chem. . 242 . 4603 - 9 . 4383524 . 20 .
- Ray M, Ray S . 1982 . On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase . J. Biol. Chem. . 257 . 10571 - 4 . 7107626 . 18 .
- Ray S, Ray M . 1982 . Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate . J. Biol. Chem. . 257 . 10566 - 70 . 7107625 . 18 .
