2-oxo-acid reductase explained

2-oxo-acid reductase
Ec Number:	1.1.99.30
Cas Number:	115299-99-5

In enzymology, a 2-oxo-acid reductase is an enzyme that catalyzes the chemical reaction

a (2R)-hydroxy-carboxylate + acceptor

\rightleftharpoons a 2-oxo-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are (2R)-hydroxy-carboxylate and acceptor, whereas its two products are 2-oxo-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (2R)-hydroxy-carboxylate:acceptor oxidoreductase. Other names in common use include (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR, and 2-oxoacid reductase.

References

• Trautwein T, Krauss F, Lottspeich F, Simon H . 1994 . The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein . Eur. J. Biochem. . 222 . 1025 - 32 . 8026480 . 10.1111/j.1432-1033.1994.tb18954.x . 3 . free .
• Neumann S, Simon H . 1985 . On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species . FEBS Lett. . 167 . 1 . 29 - 32 . 10.1016/0014-5793(84)80826-1 . free .