2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase explained

Symbol:	OHCU_decarbox
OHCU decarboxylase
Pfam:	PF09349
Interpro:	IPR018020

In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.^{[1] [2]} It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.^{[3] [4]}

Notes and References

1. Ramazzina I, Folli C, Secchi A, Berni R, Percudani R . Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes . Nat. Chem. Biol. . 2 . 3 . 144–8 . March 2006 . 16462750 . 10.1038/nchembio768 . 13441301 .
2. Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G. The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation. . J Biol Chem . 2007 . 282 . 25 . 18182–9 . 17428786 . 10.1074/jbc.M701297200 . free . 11577/1777398 . free .
3. Kim K, Park J, Rhee S. Structural and functional basis for (S)-allantoin formation in the ureide pathway. . J Biol Chem . 2007 . 282 . 32 . 23457–64 . 17567580 . 10.1074/jbc.M703211200 . free .
4. Todd CD, Tipton PA, Blevins DG, Piedras P, Pineda M, Polacco JC. Update on ureide degradation in legumes. . J Exp Bot . 2006 . 57 . 1 . 5–12 . 16317038 . 10.1093/jxb/erj013 . free .