2-Methyl-5-hydroxytryptamine explained
| Verifiedfields: | changed |
| Verifiedrevid: | 477214316 |
| Iupac Name: | 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol |
| Cas Number: | 78263-90-8 |
| Pubchem: | 1574 |
| Iuphar Ligand: | 218 |
| Chemspiderid: | 1518 |
| Kegg: | C13665 |
| Chebi: | 31085 |
| Chembl: | 266591 |
| C: | 11 |
| H: | 14 |
| N: | 2 |
| O: | 1 |
| Smiles: | Oc1cc2c(cc1)[nH]c(c2CCN)C |
| Stdinchi: | 1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3 |
| Stdinchikey: | WYWNEDARFVJQSG-UHFFFAOYSA-N |
2-Methyl-5-hydroxytryptamine (2-Methylserotonin, 2-Methyl-5-HT) is a tryptamine derivative closely related to the neurotransmitter serotonin which acts as a moderately selective full agonist at the 5-HT3 receptor.[1] [2] [3]
See also
Notes and References
- 10.1002/ardp.19933261110 . Elz S, Zimmermann H, Rehse K . Selectivity of sterically fixed tryptamine and 5-methoxytryptamine derivatives for serotonin receptor subtypes, II: Structure-activity relationships and in vitro pharmacology of N-alkyl- and N,N-dialkyl-3- indolylbicyclo-[2.2.1]-heptane-2-amines. . Archiv der Pharmazie . 326 . 11 . 893–899 . 1993 . 8274071 . 1671270 .
- Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE . 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. . Naunyn-Schmiedeberg's Arch Pharmacol . 342 . 1 . 9–16 . 1990 . 2402303 . 10.1007/bf00178965. 24743785 .
- Web site: Serotonin Receptor Subtypes and Ligands . 2008-04-11 . Glennon RA, Dukat M, Westkaemper RB . 2000-01-01 . American College of Neurophyscopharmacology . https://web.archive.org/web/20080421160353/http://www.acnp.org/g4/GN401000039/Ch039.html. 21 April 2008 . live.
