MMDA-2 explained

MMDA-2 (2-methoxy-4,5-methylenedioxyamphetamine) is a psychedelic drug of the amphetamine class.^[1] It is closely related to MMDA and MDA.^[1]

Alexander Shulgin was likely the first to synthesize MMDA-2.^[1] In his book PiHKAL, the dose is listed as 25–50 mg, and the duration is listed as 8–12 hours.^[1] Shulgin reports that MMDA-2 produces effects such as enhanced awareness, empathy, and visual facilitation and distortion, as well as some side effects like gastrointestinal upset and appetite loss.^[1] He states that 30 mg is very similar to 80 mg of MDA, and also remarks that it would be impossible for anyone to have a bad experience on the drug at that dose.^[1]

Scientific research has shown that MMDA-2, unlike MMDA, but similarly to 6-methyl-MDA, is only very weak at inducing the release of serotonin or dopamine,^[2] and accordingly, does not produce amphetamine-like responses in animals in drug discrimination studies.^[3] Instead, MMDA-2 is likely to act as a pure 5-HT₂ receptor agonist similarly to the DOx series of compounds, with activation of the 5-HT_2A receptor conferring its psychedelic effects.^[4]

MMDA-2 has been sold as a designer drug in Japan.^[5]

See also

• 2C2-NBOMe
• DMMDA

External links

• Erowid - PiHKAL entry for MMDA-2
• Isomerdesign - PiHKAL entry for MMDA-2

Notes and References

1. Book: Shulgin A, Shulgin A . MMDA-2 (2-Methoxy-4,5-methylenedioxyamphetamine) . Pihkal: A Chemical Love Story . Transform Press . 13 May 2016 . 978-0-9630096-0-9 . http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=133 .
2. McKenna DJ, Guan XM, Shulgin AT . 3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine . Pharmacology, Biochemistry, and Behavior . 38 . 3 . 505–512 . March 1991 . 1829838 . 10.1016/0091-3057(91)90005-M . 2740262 . free .
3. Glennon RA, Yousif M, Naiman N, Kalix P . Methcathinone: a new and potent amphetamine-like agent . Pharmacology, Biochemistry, and Behavior . 26 . 3 . 547–551 . March 1987 . 3575369 . 10.1016/0091-3057(87)90164-X . 5890314 .
4. Clare BW . QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens . Journal of Computer-Aided Molecular Design . 16 . 8–9 . 611–633 . 2002 . 12602954 . 10.1023/A:1021966231380 . 9948738 . 2002JCAMD..16..611C .
5. Min JZ, Shimizu Y, Toyo'oka T, Inagaki S, Kikura-Hanajiri R, Goda Y . Simultaneous determination of 11 designated hallucinogenic phenethylamines by ultra-fast liquid chromatography with fluorescence detection . Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences . 873 . 2 . 187–194 . October 2008 . 18789774 . 10.1016/j.jchromb.2008.08.020 .