2-hydroxyhexa-2,4-dienoate hydratase explained

2-hydroxyhexa-2,4-dienoate hydratase
Ec Number:	4.2.1.132

2-hydroxyhexa-2,4-dienoate hydratase (tesE (gene), hsaE (gene)) is an enzyme with systematic name 4-hydroxy-2-oxohexanoate hydro-lyase ((2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming).^[1] This enzyme catalyses the following chemical reaction

4-hydroxy-2-oxohexanoate

\rightleftharpoons (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H₂O

This enzyme catalyses a late step in the bacterial steroid degradation pathway.

Notes and References

1. Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T . Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441 . Applied and Environmental Microbiology . 71 . 9 . 5275–81 . September 2005 . 16151114 . 1214608 . 10.1128/aem.71.9.5275-5281.2005 .