2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase explained
| 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase |
| Ec Number: | 3.7.1.13 |
2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (CarC) is an enzyme with systematic name (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase.[1] [2] This enzyme catalyses the following chemical reaction
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O
anthranilate + (2E)-2-hydroxypenta-2,4-dienoate
This enzyme catalyses the third step in the aerobic degradation pathway of carbazole.
Notes and References
- Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T . Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10 . Bioscience, Biotechnology, and Biochemistry . 67 . 1 . 36–45 . January 2003 . 12619671 . 10.1271/bbb.67.36 . free .
- Riddle RR, Gibbs PR, Willson RC, Benedik MJ . Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole . Protein Expression and Purification . 28 . 1 . 182–9 . March 2003 . 12651123 . 10.1016/S1046-5928(02)00676-9 .
