2-haloacid dehalogenase (configuration-retaining) explained

2-haloacid dehalogenase (configuration-retaining)
Ec Number:	3.8.1.11

2-haloacid dehalogenase (configuration-retaining) (2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining).^{[1] [2]} This enzyme catalyses the following chemical reaction

(1) (S)-2-haloacid + H₂O

\rightleftharpoons (S)-2-hydroxyacid + halide

(2) (R)-2-haloacid + H₂O

\rightleftharpoons (R)-2-hydroxyacid + halide

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.

Notes and References

1. Weightman AJ, Weightman AL, Slater JH . Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms . Journal of General Microbiology . 128 . 8 . 1755–62 . August 1982 . 7142958 . 10.1099/00221287-128-8-1755 . free .
2. Bacterial 2-haloacid dehalogenases: Structures and catalytic properties . Soda, K. . Kurihara, T. . Liu, J.-Q. . Nardi-Dei, V. . Park, C. . Miyagi, M. . Tsunasawa, S. . Esaki, N. . Pure Appl. Chem. . 1996 . 68 . 11 . 2097–2103 . 10.1351/pac199668112097. free .