2-Deoxystreptamine N-acetyl-D-glucosaminyltransferase explained

2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
Ec Number:2.4.1.283

2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (btrM (gene), neoD (gene), kanF (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase.[1] [2] This enzyme catalyses the following chemical reaction

\rightleftharpoons

UDP + 2'-N-acetylparomamine

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics.

Notes and References

  1. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T . Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis . ChemBioChem . 9 . 6 . 865–9 . April 2008 . 18311744 . 10.1002/cbic.200700717 .
  2. Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ . Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation . Nature Chemical Biology . 7 . 11 . 843–52 . October 2011 . 21983602 . 10.1038/nchembio.671 .

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