2-dehydropantolactone reductase (B-specific) explained

2-dehydropantolactone reductase (B-specific)
Ec Number:	1.1.1.214
Cas Number:	37211-75-9
Go Code:	0019141

In enzymology, a 2-dehydropantolactone reductase (B-specific) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP⁺

\rightleftharpoons 2-dehydropantolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP⁺, whereas its 3 products are 2-dehydropantolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP⁺ oxidoreductase (B-specific). Other names in common use include 2-oxopantoyl lactone reductase, 2-ketopantoyl lactone reductase, ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (B-specific).

References

• Wilken DR, ((King HL Jr)), Dyar RE . 1975 . Ketopantoic acid and ketopantoyl lactone reductases: Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate . J. Biol. Chem. . 250 . 2311 - 4 . 234966 . 6 .