2-dehydro-3-deoxy-L-arabinonate dehydratase explained

2-dehydro-3-deoxy-L-arabinonate dehydratase
Ec Number:	4.2.1.43
Cas Number:	37263-10-8
Go Code:	0047449

The enzyme 2-dehydro-3-deoxy-L-arabinonate dehydratase catalyzes the chemical reaction

2-dehydro-3-deoxy-L-arabinonate

\rightleftharpoons 2,5-dioxopentanoate + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming). Other names in common use include 2-keto-3-deoxy-L-arabinonate dehydratase, and 2-dehydro-3-deoxy-L-arabinonate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.

References

• Stoolmiller AC, Abeles RH . 1966 . Formation of alpha-ketoglutaric semialdehyde from L-2-keto-3-deoxyarabonic acid and isolation of L-2-keto-3-deoxyarabonate dehydratase from Pseudomonas saccharophila . J. Biol. Chem. . 241 . 5764 - 71 . 5954356 . 24 .